Seiji Nishino Selected Research

Sleep Wake Disorders

1/2019	HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy.
1/2011	Hypothalamus, hypocretins/orexin, and vigilance control.
6/2008	Armodafinil for excessive daytime sleepiness.
11/2007	The hypocretin/orexin receptor: therapeutic prospective in sleep disorders.
6/2007	The hypothalamic peptidergic system, hypocretin/orexin and vigilance control.
2/2007	Neuropeptides as possible targets in sleep disorders: special emphasis on hypocretin-deficient narcolepsy.
1/2007	Neuropeptides as possible targets in sleep disorders.
8/2006	CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency?
6/2004	Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release.
12/2003	Relationship between CSF hypocretin levels and hypocretin neuronal loss.

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Seiji Nishino Research Topics

Disease

56	Narcolepsy 04/2022 - 02/2000
31	Cataplexy 01/2018 - 02/2000
21	Disorders of Excessive Somnolence (Hypersomnia) 05/2016 - 10/2002
14	Sleep Wake Disorders 01/2019 - 05/2002
10	Sleepiness 05/2016 - 05/2004
8	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2022 - 10/2002
7	Sleep Deprivation 01/2022 - 01/2004
4	Idiopathic Hypersomnia 04/2022 - 03/2002
4	Nervous System Diseases (Neurological Disorders) 04/2011 - 10/2002
3	Schizophrenia (Dementia Praecox) 01/2018 - 05/2002
3	Encephalitis (Encephalitis, Rasmussen) 01/2017 - 05/2012
3	Demyelinating Diseases (Demyelinating Disease) 12/2009 - 05/2004
3	Obstructive Sleep Apnea 02/2009 - 10/2002
2	Catatonia 01/2017 - 01/2014
2	Prader-Willi Syndrome (Syndrome, Prader-Willi) 05/2016 - 10/2002
2	Obesity 05/2016 - 09/2006
2	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2010 - 12/2003
2	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 06/2003 - 10/2002
1	Circadian Rhythm Sleep Disorders (Delayed Sleep Phase Syndrome) 01/2018
1	Glucose Intolerance 10/2017
1	Psychotic Disorders (Schizoaffective Disorder) 01/2014
1	Sleep Paralysis 09/2012
1	Myotonic Dystrophy (Dystrophia Myotonica) 08/2012
1	Mental Disorders (Mental Disorder) 05/2012
1	Teratoma (Teratoid Tumor) 05/2012
1	Timothy syndrome 11/2011
1	Autistic Disorder (Autism) 11/2011
1	Neuromyelitis Optica (Devic's Disease) 04/2011
1	Alzheimer Disease (Alzheimer's Disease) 11/2009
1	Hemorrhage 01/2008
1	Cerebral Hemorrhage 01/2008
1	Fatigue 11/2007
1	Body Weight (Weight, Body) 09/2006

Drug/Important Bio-Agent (IBA)

56	OrexinsIBA 04/2022 - 03/2002
11	Modafinil (Provigil)FDA Link 11/2016 - 07/2006
10	LigandsIBA 05/2010 - 07/2003
8	Peptides (Polypeptides)IBA 01/2019 - 01/2007
7	Hypnotics and Sedatives (Sedatives)IBA 01/2022 - 07/2006
7	Orexin ReceptorsIBA 01/2018 - 07/2003
7	Amphetamine (Amfetamine)FDA LinkGeneric 10/2011 - 06/2005
7	Sodium Oxybate (gamma Hydroxybutyrate)FDA Link 10/2011 - 06/2005
6	Histamine (Histamine Dihydrochloride)FDA Link 12/2013 - 11/2002
6	Antidepressive Agents (Antidepressants)IBA 10/2011 - 02/2000
5	Ataxin-3IBA 11/2016 - 09/2006
5	NeuropeptidesIBA 02/2007 - 11/2002
4	Dopamine (Intropin)FDA LinkGeneric 11/2011 - 11/2002
4	Central Nervous System StimulantsIBA 10/2011 - 02/2000
4	Neurotransmitter Agents (Neurotransmitter)IBA 01/2010 - 11/2002
4	HLA-DQB1 antigen (HLA DQB1)IBA 08/2006 - 10/2002
3	Adenosine (Adenocard)FDA LinkGeneric 10/2021 - 11/2002
3	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2010 - 01/2007
3	LeptinIBA 09/2006 - 01/2003
2	Histamine H1 AntagonistsIBA 01/2022 - 10/2017
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2017 - 05/2012
2	AntibodiesIBA 01/2017 - 04/2011
2	AntigensIBA 12/2013 - 06/2002
2	Pharmaceutical PreparationsIBA 12/2013 - 11/2007
2	Biological ProductsIBA 09/2012 - 10/2002
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2011 - 10/2011
2	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 10/2011 - 06/2005
2	Biomarkers (Surrogate Marker)IBA 02/2009 - 01/2003
2	Proteins (Proteins, Gene)FDA Link 02/2007 - 01/2007
2	Amino Acids FDA Link 02/2007 - 01/2007
2	CytokinesIBA 02/2007 - 01/2007
2	LipidsIBA 02/2007 - 01/2007
1	Insulin (Novolin)FDA Link 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 01/2022
1	Aripiprazole (Abilify)FDA Link 01/2018
1	Antipsychotic Agents (Antipsychotics)IBA 01/2018
1	N-Methylaspartate (NMDA)IBA 01/2014
1	Doxycycline (Periostat)FDA LinkGeneric 12/2013
1	Histidine DecarboxylaseIBA 12/2013
1	Diphtheria ToxinIBA 12/2013
1	RNA (Ribonucleic Acid)IBA 08/2012
1	PhysostigmineIBA 06/2012
1	L 644711 (B-3(+))IBA 05/2012
1	AutoantibodiesIBA 05/2012
1	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 11/2011
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 11/2011
1	Serotonin (5 Hydroxytryptamine)IBA 10/2011
1	Aquaporin 4IBA 04/2011
1	Immunoglobulin G (IgG)IBA 04/2011
1	Hormones (Hormone)IBA 01/2011
1	Venlafaxine Hydrochloride (Effexor)FDA LinkGeneric 11/2010
1	1,7-dimethylxanthine (paraxanthine)IBA 07/2010
1	Caffeine (No Doz)FDA LinkGeneric 07/2010
1	Orexin Receptor AntagonistsIBA 11/2009
1	Amyloid beta-PeptidesIBA 11/2009
1	Desipramine (Pertofrane)FDA LinkGeneric 05/2009
1	Dextroamphetamine (Dexedrine)FDA LinkGeneric 05/2009
1	AminesIBA 02/2009
1	thioperamideIBA 01/2008
1	Zolpidem (Ambien)FDA LinkGeneric 11/2007
1	AtaxinsIBA 06/2007
1	C-Reactive ProteinIBA 08/2006

Therapy/Procedure

8	Therapeutics 01/2018 - 06/2005
1	Intranasal Administration 01/2018
1	Transplantation 01/2018
1	Immunotherapy 03/2010